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In this episode of CME On the Go, our hosts revisit menopause through a case of a 51-year-old with seven months of amenorrhea, vasomotor and cognitive symptoms, and osteopenia-range DEXA findings, highlighting that she is perimenopausal. They note the limited role of FSH/LH testing and the need to rule out other causes. The episode focuses on systemic hormone therapy, recommending 17β-estradiol with progesterone for patients with an intact uterus, favoring transdermal routes for lower risk, gradual dose titration, shared decision making, and supportive lifestyle measures. Learning Objectives 1. Learn how to select proper dosing and route of administration for estrogen replacement therapy including initiation, adjustments through monitoring, and discontinuation. 2. Discuss non-medicinal strategies for healthy aging in the menopausal woman including issues around sleep management, general cardiovascular fitness, and dementia. The AAFP has reviewed Hot Takes and Flashbacks of Menopause and deemed it acceptable for up to 0.50 Enduring Materials, Self-Study AAFP Prescribed credits. Term of Approval is from 03/09/2026 to 6/4/2027. Physicians should claim only the credit commensurate with the extent of their participation in the activity. The AAFP is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The American Academy of Family Physicians designates this Enduring Materials for a maximum of 0.50 AMA PRA Category 1 credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. CME activities approved for AAFP credit are recognized by the AOA as equivalent to AOA Category 2 credit. After listening to the podcast episode, claim 0.5 AAFP credit by following the provided link. https://www.aafp.org/assessment/take/... References and Resources Menopause and Perimenopause Livestream: https://www.aafp.org/cme/all/womens/m... Menopause Management: When Hormone Therapy Is Appropriate: https://www.aafp.org/pubs/afp/issues/... Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: https://jamanetwork.com/journals/jama... Blog Article: More people than ever are interested in menopause. Family physicians should be, too: https://www.aafp.org/news/blogs/aafp-... ACOG President Says Label Change on Estrogen Will Increase Access to Hormone Therapy: https://www.acog.org/news/news-releas... https://www.webmd.com/menopause/which... https://www.ncbi.nlm.nih.gov/books/NB... https://pmc.ncbi.nlm.nih.gov/articles.... Disclosure: It is the policy of the AAFP that all individuals in a position to control content disclose any relationships with commercial interests upon nomination/invitation of participation. Disclosure documents are reviewed for potential conflicts of interest and, if identified, conflicts are resolved prior to confirmation of participation. Only those participants who had no conflict of interest or who agreed to an identified resolution process prior to their participation were involved in this CME activity. All individuals in a position to control content for this session have indicated they have no relevant financial relationships to disclose. Disclaimer: Copyright 2025. AAFP. The views presented in this broadcast are the speaker’s own and do not represent those of AAFP. The information presented is for general, educational, or entertainment purposes and should not be considered legal, health, financial, or other advice. AAFP makes no representation as to the accuracy or completeness of the information and is not responsible for results that may arise from its use. Consult an appropriate professional concerning your specific situation and respective governing bodies for applicable laws. Reference to any specific product or entity does not constitute an endorsement or recommendation by AAFP unless specifically stated otherwise. AAFP and the AAFP logo are registered trademarks of American Academy of Family Physicians.