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From America’s first surgical amphitheater to the frontier of mRNA and CAR‑T, this episode is a study in how institutions endure—and how leaders earn trust. Recorded inside Pennsylvania Hospital’s first medical library, we’re joined by Kevin Mahoney, CEO of Penn Medicine. Mahoney shares the formative moments behind his leadership style: a near‑fatal tractor accident, a nurse who caught addiction before it took root, and early lessons in labor negotiations that taught him the power of presence, empathy, and intellectual curiosity. We then go deep on what Penn does uniquely well: create knowledge and disseminate it—from CAR‑T gene therapy to the mRNA vaccine revolution—and why the real victory is not credit, but reach: cures that travel far beyond Philadelphia. Finally, we confront the present and future: policy whiplash from Washington, health equity and access, what COVID taught us about rapid innovation (including remote monitoring and “COVID Watch”), and the accelerating wave of AI in medicine—how to use it responsibly to lower cost, expand expertise, and protect the human bond no algorithm can replace. If you value clear thinking, candid leadership, and science that turns into lives saved, subscribe for more conversations from The Deep End Podcast. 👍 Like • 🔔 Subscribe • 💬 Comment: What’s the best leadership lesson you’ve learned in medicine? @penn @pennmedicine @theDIEPendPodcast #pennmedicine #UPHS #healthcareleadership #ceo #CART #mRNA #philadelphia