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"Physiological Response to the 6-Minute Frame Running Test in Children and Adults with Cerebral Palsy" INTERVIEW: Arnoud M M Edelman Bos MSc, from the Department of Rehabilitation Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands, talks about his team's research findings published in the journal: Pediatric Physical Therapy TITLE OF RESEARCH ARTICLE: "Physiological Response to the 6-Minute Frame Running Test in Children and Adults With Cerebral Palsy" DESCRIPTION: AMSTERDAM, the Netherlands—Research published in the journal Pediatric Physical Therapy has shown that young people and adults with cerebral palsy can have their physiological responses to exercise accurately assessed by using a three-wheeled “frame runner”—like a tricycle, but propelled by the rider’s legs pushing along the ground rather than pedals. The lead author of the article, Arnoud M M Edelman Bos, MSc from the Department of Rehabilitation Medicine at Amsterdam University Medical Centers in Amsterdam, the Netherlands, explains how patients with more severe impairments who could not use a tread-mill or an exercise bicycle for physiological assessment can have their cardiovascular responses accurately measured by means of the “Six-Minute Frame-Running Test” to improve physical therapy and for fitness training. REFERENCE: Pediatr Phys Ther 2022;00:1–6 “Physiological Response to the 6-Minute Frame Running Test in Children and Adults With Cerebral Palsy” AUTHORS: Arnoud M. M. Edelman Bos, MSc; Emma Hjalmarsson, Msc; Annet J. Dallmeijer, PhD; Rodrigo Fernandez-Gonzalo, PhD; Annemieke I. Buizer, PhD, MD; Jessica Pingel, PhD; Eva Pontén, PhD, MD; Ferdinand von Walden, PhD, MD; Petra E. M. van Schie, PhD INSTITUTIONS: Department Rehabilitation Medicine (Mr Edelman Bos and Drs Dallmeijer, Buizer, and van Schie), Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Rehabilitation and Development (Mr Edelman Bos and Drs Dallmeijer, Buizer, and van Schie), Amsterdam Movement Sciences, Amsterdam, the Netherlands; Division of Pediatric Neurology (Ms Hjalmarsson and Drs Pingel, Pontén, and von Walden), Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; Allied Health Professionals Function (Ms Hjalmarsson), Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden; Department of Laboratory Medicine (Drs Fernandez-Gonzalo and Buizer), Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden; Emma Children’s Hospital (Xxxxx), Amsterdam UMC, Amsterdam, the Netherlands; Department of Neuroscience (Dr Pingel), Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Pediatric Orthopedic Surgery (Dr Pontén), Karolinska University Hospital, Stockholm, Sweden. PURPOSE: To determine the physiological response and association to peak oxygen uptake of the 6-minute Frame Running Test (6-MFRT) in persons with cerebral palsy (CP). METHODS: Twenty-four participants with CP, Gross Motor Function Classification System II/III/IV, performed the 6-MFRT. Distance, peak heart rate (HRpeak), peak respiratory exchange ratio (RERpeak), and peak oxygen uptake (V ̇ o2peak) were measured. RESULTS: HR peak ranged from 146 to 201 beats per minute, RER peak from 0.94 to 1.49, 6-MFRT distance from 179 to 1220 mm and V ̇ o2peak from 0.62 to 2.18 L/min. HRpeak was achieved in 63%, RERpeak in 71%. A strong correlation was observed between 6-MFRT and V ̇ o2peak. CONCLUSIONS: The 6-MFRT represented a (near) maximum effort for 75% of the participants and the 6-MFRT can be used to estimate oxygen consumption on an individual basis.