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DNA methylation, a cornerstone of epigenetic research, is vital for understanding gene regulation and its implications in health and disease. In this week’s episode of the Everything Epigenetics podcast, I speak with David Goldberg and Nicole Renke about the latest advancements in DNA methylation tools, including Illumina's groundbreaking Methylation Screening Array (MSA). We explore the history and evolution of methylation microarrays, why they remain the gold standard for Epigenome-Wide Association Studies (EWAS), and the design process behind the MSA array. David and Nicole provide insight into the practical applications of these tools for research in aging, neurodegenerative disorders, and environmental exposures. You'll learn about: • What methylation microarrays are and why they’re essential for EWAS • The market need and vision for Illumina's new MSA array • Key features and benefits of the MSA array for researchers • The role of cell-specific methylation in advancing epigenetic studies • Insights into the technical and biological validation of the MSA array Chapters: 00:00 Welcome and Introduction 02:30 History of Methylation Microarrays 10:45 Applications of EWAS in Research 20:15 Unveiling the MSA Array: Vision and Design 35:00 Technical Validation and Biological Insights 45:30 Future Directions in DNA Methylation Research 50:00 Closing Remarks Where to Find Us: Instagram - / everythingepigenetics Twitter - / everythingepi Facebook - / everythingepigenetics Follow us on Apple Podcast - https://podcasts.apple.com/us/podcast... Spotify - https://open.spotify.com/show/2uD4PF2... YouTube - / @everythingepigenetics Visit our website for more information and resources: everythingepigenetics.com