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Roy Bahat talks with neuroscientist Bobby Kasthuri, a University of Chicago professor known for his work mapping the brain, about the real mechanics of a career in science. They cover the full arc: from deciding to become a scientist in the first place, to finding ideas worth pursuing, to navigating the tenure clock and beyond. Bobby gets candid about the money side (how scientists fund their research and what they actually get paid), the controversial role of self-promotion, and why so many published research papers turn out to be wrong. They also dig into the emotional reality of scientific life: the idealism, the disappointments, and what keeps you going. Plus, dinosaurs. Chapters: 00:00:00 – Preview 00:01:51 – Big Dino 00:05:41 – Introductions 00:12:29 – Choosing science as a vocation 00:24:13 – Idea 00:51:31 – Investigation 1:23:44 – Communication 1:36:09 – Career progression 2:05:29 – The scientific system 2:35:22 – Parting thoughts for new scientists 2:40:35 – Bobby’s students Follow Roy on LinkedIn: / roybahat Follow Roy on Bluesky: https://bsky.app/profile/roybahat.com Subscribe to Roy’s newsletter: https://bit.ly/notanewsletter Read Roy’s blog: http://roybahat.com/ Read our community-edited reference guide on how to work: https://www.thisisnotadvice.work/ #thisisnotadvice