WG/GLIMPRINT Virtual Seminars: Scacchi, Small RNAs in Leaf Polarity, October 30, 2025 скачать в хорошем качестве

WG/GLIMPRINT Virtual Seminars: Scacchi, Small RNAs in Leaf Polarity, October 30, 2025

Mobile Small RNAs and Turing Patterns: Coordinating Leaf Polarity and Shape Diversity Emanuele Scacchi Winner of the 2025 OpenVT Reproducible Modeling Competition University of Tübingen, Germany The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of adaxial–abaxial (top–bottom) polarity. The patterning principles controlling the spatial arrangement of these domains during organ growth have remained unclear. Here we show that this regulation in Arabidopsis thaliana is achieved by an organ-autonomous Turing reaction‐diffusion system centred on mobile small RNAs. The data illustrate how Turing dynamics transiently instructed by prepatterned information is sufficient to self‐sustain properly oriented polarity in a dynamic, growing organ, presenting intriguing parallels to left–right patterning in the vertebrate embryo. Computational modelling demonstrates that this self-organizing system continuously adapts to coordinate the robust planar polarity of a flat leaf while affording flexibility to generate the tissue patterns of evolutionarily diverse organ shapes. Our findings identify a small-RNA-based Turing network as a dynamic regulator of organ polarity that accounts for leaf shape diversity at the level of the individual organ, plant or species. For more information see: https://www.nature.com/articles/s4147... Runnable Version of the Model: https://morpheus.gitlab.io/author/e.-... Contents 00:00 - Introduction 02:47 - Mobile Small RNAs and Turing Patterns: Coordinating Leaf Polarity and Shape Diversity 37:27 - Questions and Discussion For a copy of the slides for this video visit: https://drive.google.com/file/d/10H6p... Moderator: James A. Glazier If you found this video useful, please check out our other videos on computational modeling, infection and immunology:    • IMAG/MSM WG and GLIMPRINT Seminars on Mult...   Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/co... Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/