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Summary: This presentation describes what ocular graft-versus-host disease (oGVHD) is, its causes, signs and symptoms, and current management and treatment options. Presenter: Zhonghui Katie Luo MD, PhD Massachusetts Eye and Ear https://www.massgeneral.org/doctors/1... This presentation took place at the May 3-9, 2025 Survivorship Symposium. Many thanks to Incyte Corporation and Sanofi whose support, in part, made this presentation possible. Presentation is 42 minutes with 19 minutes of Q & A To read the transcript, go to: https://bmtinfonet.org/video/graft-ve... Highlights: (06:15): Patients who undergo a bone marrow/stem cell transplant with donor cells (allogeneic transplant) have a 50% chance of getting graft-versus-host disease in the eyes, regardless of whether other organs are affected by GVHD. (08:35): A common sign for spotting a patient with ocular GVHD is that they're typically squinting, and they often wear sunglasses indoors because their eyes are very dry. (13:37): Ocular GVHD often occurs after an immunogenic event – an event that triggers an immune system response, such as receiving a vaccine. (14:57): If eye lesions caused by oGVHD are treated early and aggressively, there is less scarring. (19:40): When the surface of the eye is that dry, and the oil and tear production are deficient, the surface can break down because healing is severely compromised. Erosion can occur, and in just days, the cornea can actually melt. (24:19): There are things we can be mindful of to avoid exacerbation of oGVHD, including not touching your eyes, using only preservative-free eye medications, limiting time spent staring at screens, and being careful when putting on and removing makeup. (30:32): Punctal plugs and punctal cautery can help maintain eye lubrication. (33:04): Steroids and serum tears are two other treatment options. (34:25): The therapeutic scleral lens is another lifesaver for many patients. (35:41): Any cosmetic surgery of the lids or the eyes, and LASIK surgery should be avoided. Key Points: Ocular graft-versus-host disease (oGVHD) occurs when the donor’s immune system attacks and damages some of the tissue in the eyes. This decreases tear and oil production and causes scarring. As a result, the patient develops very dry eyes. Symptoms include increased discharge and tearing, followed by significant dryness and damage to the eyes. Patients aren’t usually aware of these early symptoms of oGVHD, which often causes a delay in treatment and increases the damage to the eyes. -There are many interventions that patients can utilize to help improve and manage their oGVHD, including lifestyle modifications, over-the-counter and pharmacological eye drops and oral medications, medical procedures, and surgeries. VISIT US ON SOCIAL MEDIA: / bmtinfonet / bonemarrowstemcelltransplantclub / bmtinfonet https://x.com/BMTInfoNet / bmt-infonet https://bsky.app/profile/bmtinfonet.b...