Synthesis Workshop: Synthesis of Panowamycins, TM-135, and Veramycin F with Dr. Ben Bergstrom ( скачать в хорошем качестве

Synthesis Workshop: Synthesis of Panowamycins, TM-135, and Veramycin F with Dr. Ben Bergstrom (

In this Research Spotlight episode, Dr. Ben Bergstrom (alumnus of Shaw group, UC Davis) joins us to share his work on the total synthesis of panowamycins, TM-135, and veramycin F. Key reference: Angew. Chem. Int. Ed. 2022, 61, e202203072. https://doi.org/10.1002/anie.202203072 Other references (in order of appearance): Isolation paper: J. Antibiot. 2012, 65, 197-202. Methodology paper: Chem. Sci., 2020,11, 494-498; for pioneering work with carbene insertion reactions, see J. Am. Chem. Soc. 1991, 113, 8982– 8984 and J. Am. Chem. Soc. 1997, 119, 9075–9076. For more on chiral dirhodium catalysts, see: Coord. Chem. Rev. 2008, 252, 545–555, J. Am. Chem. Soc. 2016, 138, 3797–3805, and Catalysts 2018, 8, 268. For enolate addition/reduction sequence see: J. Am. Chem. Soc. 2000, 122, 10033–10046. For more on the reduction/acylation/addition sequence, see: Org. Lett. 2018, 20, 3021–3024. J. Nat. Prod. 2021, 84, 2411–2419. Org. Chem. Front. 2022, 9, 1604–1615.