IL-17A mediated neutrophil recruitment for controlling colonisation скачать в хорошем качестве

IL-17A mediated neutrophil recruitment for controlling colonisation

To cite: Waldschmitt N, Kitamoto S, Secher T, et al. Gut 2019;68:1190-1199. Read the full article here: http://dx.doi.org/10.1136/gutjnl-2018.... Objective: Loss of the Crohn’s disease predisposing NOD2 gene results in an intestinal microenvironment conducive for colonisation by attaching-and-effacing enteropathogens. However, it remains elusive whether it relies on the intracellular recruitment of the serine-threonine kinase RIPK2 by NOD2, a step that is required for its activation of the transcription factor NF-κB. Conclusions: These results unveil a previously unrecognised mechanism that efficiently protects from colonisation by diarrhoeagenic bacteria early in infection.