Nitric Oxide (NO), eNOS, cGMP & Nitrate Drugs (nitroglycerin)n【For Med & Pharmacy Students】 скачать в хорошем качестве

Nitric Oxide (NO), eNOS, cGMP & Nitrate Drugs (nitroglycerin)n【For Med & Pharmacy Students】

🎓 Med School. Pharmacy School. MCAT. It’s not just the facts — it’s the overwhelm. You’ve got mountains of pathways, mechanisms, and drugs to memorize. But what if, in just 5 minutes, you could understand the entire nitric oxide pathway — and finally make sense of how nitrates like nitroglycerin relieve angina? This video is your shortcut to clarity. 🧠 In this short yet powerful lesson, you’ll discover: Why your body makes a gas (NO) to dilate blood vessels How shear stress and hypoxia trigger NO production The full cascade: eNOS → NO → sGC → cGMP → PKG → Smooth muscle relaxation How this same pathway explains the life-saving effect of nitrate drugs And most importantly — how this knowledge sticks, because you’ll understand, not just memorize. 🫀 Whether you’re preparing for USMLE, NCLEX, MCAT, or struggling in your cardio module — this video is made for you. Because when it finally clicks… you’ll remember it forever. 📚 Keywords for Search: nitric oxide, NO, eNOS, cGMP, vasodilation, nitrate drugs, nitroglycerin, smooth muscle relaxation, PKG, guanylate cyclase, USMLE Step 1, pharmacology made easy, medical student, endothelial cells, ALDH2, NO pathway #pharmacologymadeeasy #NitricOxide #NitrateDrugs #enos #cgmp #usmle #mcat #medstudentlife #pharmacyschool #biochemistryreview #anginatreatment #smoothmusclerelaxation #GuanylateCyclase #PKGPathway 【🎬 Video Chapters: How Nitroglycerin Helps During a Heart Attack – The Secret of Nitric Oxide】 ⏱ 0:00 – Why You NEED to Understand Nitric Oxide 🎙 “I’m NO — a gas with superpowers. I travel between cells to send important messages.” ⏱ 0:28 – What is NO and How Is It Made? 🎙 “I’m made from arginine by an enzyme called NO synthase — especially eNOS in blood vessels.” ⏱ 0:59 – Exercise and Hypoxia: When NO Gets Activated 🎙 “NO is activated when your body needs more blood flow—like during exercise or low oxygen (hypoxia).” ⏱ 1:15 – How Exercise Boosts Nitric Oxide: The Power of Shear Stress? 🎙 “During exercise, blood flow speeds up, causing shear stress — and that activates eNOS.” How NO Triggers Vasodilation (eNOS → NO → sGC → cGMP) ⏱ 2:00 – HIF-1α and Chemical Signals 🎙 “When oxygen stays low, HIF-1α (Hypoxia-Inducible Factor 1-alpha) and chemicals like adenosine and histamine boost NO production.” ⏱ 2:50 – How NO Relaxes Smooth Muscle 🎙 “NO enters smooth muscle → activates sGC → produces cGMP → relaxation and vessel dilation.” ⏱ 3:17 – PKG and the 3-Part Relaxation Strategy 🎙 “PKG turns off contraction by lowering calcium, blocking calcium channels, and relaxing muscle.” ⏱ 4:18 – How Nitrates Work: Nitrates Mechanism of Action Explained 🎙 “Nitrates like nitroglycerin enter smooth muscle, are converted to NO by ALDH2, and cause vasodilation. For exams, remember: NO → sGC → cGMP → PKG → vasodilation. Nitrates use this pathway too!