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http://www.le.ac.uk/ http://www.le.ac.uk/csn Brain scientists in the UK and US have collaborated to make ‘a spectacular discovery’ - for the first time in human studies - of how memories are formed and new learning takes place. A collaboration between Dr Matias Ison and Professor Rodrigo Quian Quiroga at the Centre for Systems Neuroscience University of Leicester, and Dr Itzhak Fried at Ronald Reagan UCLA Medical Center revealed how a neuron in the brain instantly fired differently when a new memory was formed. The research group at Leicester and UCLA had previously announced the ‘Jennifer Aniston neuron’ –the firing of a single neuron for a single image to form a concept. The team has now proved their hypothesis to be true- and has gone further to demonstrate how new memories are formed. The scientists showed patients images of a person in a context e.g. Jennifer Aniston at the Eiffel Tower, Clint Eastwood in front of the Leaning Tower of Pisa, Halle Berry at the Sidney Opera House or Tiger Woods at the White House. They found that the neuron that formerly fired for a single image e.g. Jennifer Aniston or Halle Berry, now also fired for the associated image too i.e. the Eiffel Tower or Sidney Opera House. “The remarkable result was that the neurons changed their firing properties at the exact moment the subjects formed the new memories - the neuron initially firing to Jennifer Aniston started firing to the Eiffel Tower at the time the subject started remembering this association,” said Rodrigo Quian Quiroga, head of the Centre for Systems Neuroscience at the University of Leicester. “Moreover, we observed these changes after just a single presentation. This is a radical departure from previous experiments in animals where changes have been observed mainly after long training sessions. This is critical to understanding the neural processes underlying real-life memory formation, as in real life we are not repeatedly exposed to an event in order to remember it - just one exposure is enough.” The researchers from the University of Leicester and Ronald Reagan UCLA Medical Center have published their research in the peer-reviewed leading journal Neuron. The research was supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH), Medical Research Council (MRC), the Human Frontiers Science Program and the Mathers Foundation.