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The CASP (Critical Assessment of protein Structure Prediction) competition, organized by the Prediction Center (predictioncenter.org), is the premier event for evaluating computational protein structure prediction methods. It provides researchers with unknown protein structures as targets, fostering innovation and benchmarking progress in the field. At a recent CASP conference, David Baker, a leading figure in protein design, delivered a keynote address on "De Novo Protein Design Using Deep Learning." His presentation highlighted the transformative potential of artificial intelligence in creating novel proteins from scratch, a topic highly relevant to the CASP community focused on predicting and understanding protein structures. Baker's talk offered insights into how deep learning is revolutionizing protein engineering, complementing the core mission of CASP to advance our understanding of protein folding and function. The intersection of Baker's work with the CASP assessment underscores the importance of computational methods in tackling fundamental challenges in protein science. David Baker is a world-renowned biochemist and computational biologist whose groundbreaking work has revolutionized the field of protein design. His pioneering efforts have focused on understanding and manipulating the intricate process of protein folding, leading to the development of powerful computational tools for predicting and designing protein structures. Baker's lab has been at the forefront of de novo protein design, creating novel proteins with functions not found in nature. His contributions have earned him numerous accolades, including the prestigious Nobel Prize in Chemistry. Baker's insights into protein science have broad implications for medicine, materials science, and biotechnology, paving the way for the development of new therapies, diagnostics, and sustainable solutions. He is also known for his involvement with the CASP (Critical Assessment of protein Structure Prediction) competition, a crucial event for advancing the field of protein structure prediction.