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Funded by the National Institutes of Health, Drs. Hains and Schwaderer have linked in to the national, multi-center RIVUR (Randomized Intervention for Children with Vesicoureteral Reflux) study. The RIVUR study involves 600 children with reflux who have had at least one urinary tract infection. The children are separated into two groups: those who have been on antibiotics and those who have not. This two-year study will investigate whether being on an antibiotic makes a difference in infection rate in children with reflux. Using these groups, Drs. Hains and Schwaderer are performing an ancillary study to examine each child's entire genome in search of genes that might cause reflux and factors that cause infections. So far, they are the only scientists who have been granted access to the RIVUR DNA repository.