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Why time seems to fly during good times, and crawl during bad? Joe Paton, principal investigator at the Champalimaud Centre for the Unknown, is one step closer to explaining how and why, neurologically speaking, our brain keeps track of time. By training mice on tasks that depend on their sense of time, Joe’s team was able to identify specific neurons involved with the processing of time in the mouse brain. As undergraduate, Joe studied the organization of central pattern generators in the nerve cord of the larval Manduca sexta caterpillar at Tufts University and genetic determinants of cell fate during development in Drosophila melanogaster at Harvard Medical School. After university, Joe moved to California to work as a research technician at Stanford University studying neural mechanisms of vision and decision making. In 2001, Joe moved back to the east coast of the U.S. to start work towards his PhD at Columbia University where he studied the neural mechanisms that underlie learning to predict rewards and punishments. In 2008, Joe received his PhD with distinction and joined the Champalimaud Foundation’s research programme, where his laboratory studies the neural circuit mechanisms of cognitive processes. He is currently a principal investigator within Champalimaud Research, at the Champalimaud Centre for the Unknown in Lisbon, Portugal. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx