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In this episode, I speak with Professor Nikita Nekrasov, one of the most original minds in theoretical physics. We dive into why quantum field theory still isn’t fully understood, despite its experimental success and why a complete axiomatic foundation might not even be possible. Nikita walks us through his solution to the Seiberg-Witten puzzle, the birth of the Nekrasov partition function, and how exotic structures in four dimensions could underlie the chemistry of life. This conversation blends deep math, quantum weirdness, and personal stories from the front lines of discovery. If you’ve ever wondered what it really means to understand reality, this one’s for you. As a listener of TOE you can get a special 20% off discount to The Economist and all it has to offer! Visit https://www.economist.com/toe Join My New Substack (Personal Writings): https://curtjaimungal.substack.com Listen on Spotify: https://open.spotify.com/show/4gL14b9... Timestamps: 00:00 Introduction 01:13 Understanding Quantum Field Theory 04:38 The Journey to Gauge Origami 06:53 The Story of the Nekrasov Partition Function 19:12 Connecting Quantum Mechanics and Field Theory 36:43 The Nature of Instantons 45:05 Exotic R4 and Its Implications 49:01 Dealing with Non-Compactness 52:25 The Emergence of Non-Commutative Geometry 1:04:29 Lessons from Mentors 1:20:11 Language as a Dynamic System 1:22:35 The Concept of Gauge Origami 1:30:48 Insights from Collaboration with Peers 1:37:15 Aspirations for Future Work 1:38:15 Advice for Aspiring Researchers Links Mentioned: • Nikita’s Papers: https://scholar.google.com/citations?... • Nikita’s Lecture: https://scgp.stonybrook.edu/archives/... • Two Dimensional Gauge Theories [Paper]: https://arxiv.org/pdf/hep-th/9204083 • Richard Borcherds [TOE]: • Richard Borcherds: E8, Witten, Langlands, ... • Edward Frenkel [TOE]: • Edward Frenkel: Infinity, Ai, String Theor... • Edward Frenkel’s Presentation [TOE]: • Revolutionary Math Proof No One Could Expl... • Edward Frenkel’s Presentation [Part 2]: • Geometric Langlands: The Largest Breakthro... • String Theory Iceberg [TOE]: • The Mathematics of String Theory [Graduate... • Roger Penrose [TOE]: • Roger Penrose: Quantum Theory Is Wrong, No... • Cumrun Vafa [TOE]: • Dark Dimensions: NEW THEORY Unifying Dark ... • Garrett Lisi [TOE]: • The 248 Dimensional Object That Unifies th... • Chiara Marletto [TOE]: • The Groundbreaking Quantum Gravity Experiment • Debunking “All Possible Paths” [TOE]: • Debunking the “All Possible Paths” Myth: W... • Peter Woit [TOE]: • The Forgotten Geometry: A New Path to Unif... • Leonard Susskind [TOE]: • The Crisis in String Theory is Worse Than ... • Seiberg-Witten Prepotential from Instanton Counting [Paper]: https://arxiv.org/pdf/hep-th/0206161 • Eva Miranda [TOE]: • Geometric Quantization: The Bridge from Cl... • Leptons and Quarks [Book]: https://www.amazon.com/LEPTONS-QUARKS... • Brian Greene [TOE]: • Cutting Edge Traversable Wormholes Researc... • David Wallace [TOE]: • The Many-Worlds Interpretation of Quantum ... • Jenann Ismael [TOE]: • The Physics of Free Will: A Radical New Th... • Claudia de Rham [TOE]: • The Physicist Who Broke an "Unbreakable" R... • Yang-Mills [Paper]: https://arxiv.org/pdf/2504.19097 SUPPORT: Become a YouTube Member (Early Access Videos): / @theoriesofeverything Support me on Patreon: / curtjaimungal Support me on Crypto: https://commerce.coinbase.com/checkou... Support me on PayPal: https://www.paypal.com/donate?hosted_... SOCIALS: Twitter: / toewithcurt Discord Invite: / discord #science #physics