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In this video, we explore the fascinating journey of image-guided neurosurgery—from its early beginnings in stereotactic surgery in the early 1900s, through the revolutionary arrival of CT, MRI, and neuronavigation in the 1990s, to the cutting-edge applications of augmented reality, robotics, and AI today. What started as a mechanical system to reach deep brain structures has evolved into a GPS for the brain, guiding surgeons with submillimeter accuracy in tumour resections, biopsies, epilepsy procedures, and vascular surgery. We also highlight modern breakthroughs such as AR overlays in cranial and spinal surgery, robotic platforms like the NeuroArm, and AI-driven navigation systems like Zeta Surgical’s frameless cranial platform. Image-guided neurosurgery is not just a tool—it’s a century-long story of innovation that continues to redefine what is possible in the operating room.