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DHEA and Pregnenolone are powerful hormones. In this Lecture by Dave Lee he discusses: dhea for men, pregnenolone for men, dhea benefits, pregnenolone benefits, dhea dosage, pregnenolone dosage, dhea and pregnenolone on TRT (testosterone replacement therapy), and much more! ➜➜ WATCH Part 2 (Follow-Up) of this Lecture here: • Pregnenolone and DHEA Supplement - Le... 00:00 intro 02:35 Understand the function and importance of hormones in the brain. 06:56 Pregnenolone serves as a reservoir for the body. 09:09 Pregnenolone sulfate acts as a negative allosteric modulator of GABA receptor. 13:40 Pregnenolone benefits brain health and function. 16:04 DHEA metabolizes into various hormones with implications on HRT. 20:13 DHEA and DHEAs work together to protect and support the brain. 22:26 DHEA at high doses improved depression symptoms 26:57 Supplementing with pregnenolone and DHEA may support hormone levels. 29:06 Pregnenolone effects vary, can induce sleep or wakefulness depending on individual biochemistry. 33:17 DHEA and pregnenolone effects depend on sulfated forms and enzyme production. 35:41 Micronized sustained release oral form bypasses liver metabolism for slow absorption 39:48 DHEA recommendations range from 1 to 100 milligrams, but dosages vary based on individual needs and quality of supplements. 42:01 Cortisol is essential for survival 46:32 DHEA is preferentially converted into estrogen and estradiol when on TRT, so optimal dosing is crucial. 48:46 Ensure optimal cholesterol levels for hormone balance 53:22 Regular blood work is crucial for monitoring Pregnenolone and DHEA levels over time. 55:29 Optimizing hormone levels is key for individual well-being. 59:46 Optimizing DHEA and pregnenolone levels is crucial for older individuals 1:01:58 Gradually increase hormonal supplements for better results 1:05:54 Hormone balance is crucial for feeling good. 1:08:02 Work with a doctor for hormone management to avoid negative effects. #trtandhormoneoptimization #trt #hormoneoptimization Recommended DHEA: https://amzn.to/3lyC3Pu Recommended Pregnenolone: https://amzn.to/31K9WF7 Links provided by Dave Lee: https://www.sciencedirect.com/science... Kliewer SA, Lehmann JM, Milburn MV, Willson TM (1999). "The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways". Recent Prog. Horm. Res. 54: 345–67, discussion 10548883. https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.sciencedirect.com/science... https://books.google.com.au/books?id=... Schulman RA, Dean C (2007). Solve It With Supplements. New York City: Rodale, Inc. p. 100 http://www.ncbi.nlm.nih.gov/pmc/artic... https://www.sciencedirect.com/science... https://link.springer.com/article/10.... https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... http://www.ncbi.nlm.nih.gov/pmc/artic... http://www.ncbi.nlm.nih.gov/pmc/artic... http://www.ncbi.nlm.nih.gov/pmc/artic... http://www.ncbi.nlm.nih.gov/pmc/artic... https://www.sciencedirect.com/science... https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pubmed/2... ********************************************************** ➤Subscribe for more free information on TRT and Hormone Optimization: https://goo.gl/ZyfZyN ********************************************************** ➤Connect with us: ⇨ The Lifting Dermatologist Youtube Channel: / theliftingdermatologistnederlandskanaal ⇨ Our Facebook Group "TRT and Hormone Optimization": / hormoneoptimization ⇨ Instagram: / trt.hormone.optimization ⇨ Twitter: / stevendrdevosc1 **********************************************************