617-The Origins of Medulloblastoma скачать в хорошем качестве

617-The Origins of Medulloblastoma

The paper describes the discovery of Nestin-expressing progenitors (NEPs), a previously unidentified type of cell in the developing cerebellum. While Nestin is typically a marker for multi-use stem cells, researchers found that these specific NEPs are committed solely to becoming granule neurons. These cells are distinct from the more common granule neuron precursors (GNPs) because they reside in a different layer of the cerebellum and remain quiescent rather than rapidly dividing. Crucially, NEPs lack robust DNA repair mechanisms, making them highly susceptible to genetic errors. The study demonstrates that when certain signaling pathways are overactive, these cells are more likely than GNPs to undergo genomic instability. Consequently, NEPs appear to be a primary cell of origin for medulloblastoma, a common type of brain tumor. References: • Li P, Du F, Yuelling L W, et al. A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity[J]. Nature neuroscience, 2013, 16(12): 1737-1744.