Intelligent Image-Activated Cell Sorting - Prof Keisuke Goda (5 Sep 2019) скачать в хорошем качестве

Intelligent Image-Activated Cell Sorting - Prof Keisuke Goda (5 Sep 2019)

A fundamental challenge of biology is to understand the vast heterogeneity of cells, particularly how the spatial architecture of cells is linked to their physiological function. Unfortunately, conventional technologies are limited in uncovering these relations. In this talk, I introduce a machine intelligence technology known as “Intelligent Image-Activated Cell Sorting” [1, 2] that builds on a radically new architecture that realizes real-time image-based intelligent cell sorting at an unprecedented rate. This technology integrates high-throughput cell microscopy, focusing, sorting, and deep learning on a hybrid software-hardware data-management infrastructure, enabling real-time automated operation for data acquisition, data processing, intelligent decision-making, and actuation. I also show a few groundbreaking applications of the technology and introduce its related methods [3, 4]. The technology is highly versatile and expected to enable machine-based scientific discovery in biological, pharmaceutical, and medical sciences. [1] Nitta et al., Cell (2018) [2] Isozaki et al., Nature Protocols (2019) [3] Suzuki et al., PNAS (2019) [4] Hiramatsu et al, Science Advances (2019)