Thianthrenium Salts as New Synthetic Linchpin скачать в хорошем качестве

Thianthrenium Salts as New Synthetic Linchpin

In this episode we analyze a set of papers from the Ritter lab where they describe a new methodology for highly selective C–H functionalization reactions. Using thianthrenium salts as a synthetic linchpin, the Ritter lab demonstrates para selective amination, trifluoromethylation, and C–C cross-coupling reactions each in an effective two-step synthesis. Nature Paper: https://doi.org/10.1038/s41586-019-09... JACS Paper: https://doi.org/10.1021/jacs.9b07323 Angew Paper: https://doi.org/10.1002/anie.201906672 References: Ritter, T.; Ye. F.; Berger, F.; Jia, H.; Ford, J.; Wortman, A.; Borgel, J.; Genicot, C. Angew. Chem. Int. Ed. 2019, ASAP. Engl, P. S.; Häring, A. P.; Berger, F.; Berger, G.; Pérez-Bitrián, A.; Ritter, T. J. Am. Chem. Soc. 2019, ASAP. Berger, F.; Plutschack, M. B.; Riegger, J.; Yu, W.; Speicher, S.; Ho, M.; Frank, N.; Ritter, T. Nature 2019, 567, 223–228. Yang, L.; Correia, C. A.; Li, C.-J. Org. Biomol. Chem. 2011, 9, 7176–7179. Ham, W. S.; Hillenbrand, J.; Jacq, J.; Genicot, C.; Ritter, T. Angew. Chem. Int. Ed. 2019, 58, 532–536. Shine, H. J.; Silber, J. J. J. Org. Chem. 1971, 36, 2923–2926. Kim, K.; Hull, V. J.; Shine, H. J. J. Org. Chem. 1974, 39, 2534–2537. Shin, S.-R.; Shine, H. J. J. Org. Chem. 1992, 57, 2706–2710.    • Site-selective C-H functionalization by th...