Loss of TFF2 in Pancreatic Duct Glands results in the formation of IPMN, Junpei Yamaguchi, MD, PhD скачать в хорошем качестве

Loss of TFF2 in Pancreatic Duct Glands results in the formation of IPMN, Junpei Yamaguchi, MD, PhD

APA/Hirshberg Symposium: Celebrating 10 Years of the Hirshberg Seed Grant The 2013 Winner of the Hirshberg Award for Best Basic Science Abstract in Pancreatic Cancer Presented to: Junpei Yamaguchi, MD, PhD Massachusetts General Hospital and Harvard Medical School Loss of TFF2 in Pancreatic Duct Glands (PDG) results in the formation of IPMN suggesting TFF2 may function as a tumor suppressor. Background: PDG are a novel epithelial progenitor compartment important for regeneration of the ductal epithelium. Our early correlative studies suggest that dysregulation of this compartment may result in formation of IPMN. This compartment uniquely expresses trefoil family factor 2 (TFF2). PDG functionally and molecularly resemble gastric glands. In the stomach　TFF2 has been reported to be the tumor suppressor of gastric cancer, suggesting that TFF2 also act as the tumor suppressor to prevent the initiation of pancreatic mucinous neoplasms. Abstract Conclusions: TFF2 act as the tumor suppressor in PDG. This effect may be mediated by its effect on SMAD 4.