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Michael A. Gorin, MD, delivers a 27-minute presentation on performing transperineal prostate biopsy under local anesthesia in the office setting. He introduces his technique integrating 3D ultrasound with the KOELIS Trinity system and the PrecisionPoint Transperineal Access System, emphasizing its safety and efficacy. He shares step-by-step procedural details, including images and video, to illustrate how to target lesions. Dr. Gorin shares the advantages of the transperineal approach over the traditional transrectal method, particularly in minimizing infectious complications caused by rectal mucosa puncture. Data from randomized controlled trials demonstrate a significant reduction in post-biopsy infections. Gorin asserts that a key component of success lies in achieving adequate local anesthesia, which is accomplished through a combination of pudendal nerve block, periapical triangle block, and prostate apex block. He shares a video of a numbing procedure, with step-by-step instructions. Once numbing has been achieved, he shows how the biopsy is performed.