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Today, we will examine two of the most infamous royal families in fiction and real history, the Targaryens and the Ptolemies. The two dynasties are notorious for practicing incest, but which family was the most incestuous? I will analyze and compare the inbreeding and genetics of Daenerys Targaryen with the Ptolemaic Dynasty's Cleopatra to figure out who was the most inbred... I hope you enjoy and learn something new. Chapters: 0:00:00 Introduction 0:01:43 What is Inbreeding? 0:03:09 Calculating Inbreeding 0:10:18 The Ethnicity of Cleopatra 0:13:36 Cleopatra's Family Tree and Inbreeding 0:23:00 The Ptolemy Paradox 0:27:36 Meet the Targaryens 0:28:38 Daenerys' Family Tree and Inbreeding 0:37:35 Dany vs. Cleo 0:38:42 Ned Stark & Conclusion Citations Ager, S. L. (2005). Familiarity breeds: incest and the Ptolemaic Dynasty. The Journal of Hellenic studies, 125, 1–34. https://doi.org/10.1017/s007542690000... Alvarez G, Ceballos FC, Quinteiro C (2009) The Role of Inbreeding in the Extinction of a European Royal Dynasty. PLoS ONE 4(4): e5174. doi:10.1371/journal.pone.0005174 Bannasch, D., Famula, T., Donner, J., Anderson, H., Honkanen, L., Batcher, K., Safra, N., Thomasy, S., & Rebhun, R. (2021). The effect of inbreeding, body size and morphology on health in dog breeds. Canine medicine and genetics, 8(1), 12. https://doi.org/10.1186/s40575-021-00... Beuchat , C. (2015, June 4). COI FAQS: Understanding the Coefficient of Inbreeding. The Institute of Canine Biology. https://www.instituteofcaninebiology.... Bevan, E. R. (1927). The House of Ptolemy. Methuen Publishing, London. Chu, E. T., Simpson, M. J., Diehl, K., Page, R. L., Sams, A. J., & Boyko, A. R. (2019). Inbreeding depression causes reduced fecundity in Golden Retrievers. Mammalian Genome, 30(5), 166-172. Dodson, A., & Hilton, D. (2004). The Complete Royal Families of Ancient Egypt: A genealogical sourcebook of the pharaohs. Thames & Hudson. Grant, M. (1972), Cleopatra. London: Weidenfeld and Nicolson; Richard Clay (the Chaucer Press). Karev, E. (2025). Physical descriptions, biometrics, and eikonographia in Graeco-Roman papyri from Egypt. Brill. Ralph, P., & Coop, G. (2013). The geography of recent genetic ancestry across Europe. PLoS biology, 11(5), e1001555. https://doi.org/10.1371/journal.pbio.... Roller, D. W. (2012). Cleopatra: A biography. Oxford University Press. Schiff, S. (2011). Cleopatra: A Life. UK: Random House. Wilkinson, T. (2025). The Last Dynasty: Ancient egypt from Alexander the Great to Cleopatra Toby Wilkinson. W. W. Norton & Company. Background Music licensed from Epidemic Sound. Special thanks to Jack for going to museum with me and taking really good pictures :)