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Fast Dark Spot Remover. Fastest Dark Spot Treatment. Differin Dark Spot Correcting Serum. How to Get Rid of Dark Spots. Niacinamide for Dark Spots. Differin Niacinamide 4% 👉 https://amzn.to/41wFGJz Differin Adapalene 👉 https://amzn.to/3LJ8fNR The Ordinary Ascorbic Acid Plus Arbutin 👉 https://amzn.to/3KYZakY Vitamin C Serum for Dark Spots 👉 https://amzn.to/3mAQkQX Tranexamic Acid for Hyperpigmentation 👉 https://amzn.to/3ZtCJsc Sunscreen for Hyperpigmentation 👉 https://amzn.to/3KcrAHH Moisturizer for Hyperpigmentation 👉 https://amzn.to/3wlQqNE Follow Me on Instagram 😃 👉 / arsalanaspires How to Treat Post Inflammatory Hyperpigmentation ➡️ • Post Inflammatory Hyperpigmentation | Trea... How to Use Resveratrol for Dark Spots ➡️ • Resveratrol for Dark Spots and Redness | T... How to Use Tranexamic Acid for Dark Spots ➡️ • Tranexamic Acid for Hyperpigmentation | Ho... How to Use Retinol for Dark Spots ➡️ • Retinol for Beginners | 5 Retinol MISTAKES... How to Use Rosehip Oil for Dark Spots ➡️ • Rosehip Oil for Dark Spots in Melasma and ... How to Use Niacinamide for Dark Spots ➡️ • The Ordinary Niacinamide 10 + Zinc 1 | Sta... How to Use Alpha Arbutin for Dark Spots ➡️ • Alpha Arbutin 101 | Everything You Need to... How to Use Vitamin C for Dark Spots ➡️ • Vitamin C Serum for Dark Spots | How to Us... How to Use Azelaic Acid for Dark Spots ➡️ • Azelaic Acid for Melasma | How to Use Azel... How to Use Kojic Acid for Dark Spots ➡️ • Kojic Acid for Dark Spots and Melasma | Th... Timeline | Chapters 00:00 - Intro 1:00 - Why Use it? 1:47 - Dark Spot Pathway 3:14 - How Niacinamide Works? 3:39 - What Percentage Works? 4:38 - Sea Buckthorn 5:21 - How To Use It? Differin Dark Spot Correcting Serum. Differin Niacinamide 4 The formulation used to have 2% hydroquinone, remember? Under the 2020 Cares Act, hydroquinone became prescription only. So this is the new reformulated version, which has 4% niacinamide. Does Niacinamide Help With Dark Spots? Now differin is a really popular brand here in the US. Arguably one of their most sought after products was their adapalene gel, for those who wanted to get an alternative to tretinoin, and wanted a product that was more stable. Largely, thanks to its 3 aromatic rings. What Causes Melasma, Hyperpigmentation, and Dark Spots? We have our melanocyte here right, which are your skin cells that make pigment and give you those dark spots. You also have dark spot triggers like solar radiation, irritation, and hormones to name a few right. When they make contact to our skin, tyrosinase gene expression takes place. Afterwards, glycosylation occurs, which is fancy for a sugar getting added on to change the molecule to make it activated tyrosinase. This is where you have your tyrosinase inhibitors to come in and block them to stop this pathway. Next, your melanin gets packed into melanosomes. Which are those tiny organelles inside the melanocyte that synthesizes the pigment. Then the melanosomes start to move into the keratinocytes. Next the melanosome transfer takes place. Niacinamide comes in as the last part of this pathway and stops this. How does Niacinamide Help Hyperpigmentation? “Niacinamide is an effective skin lightening compound that works by inhibiting melanosome transfer from melanocytes to keratinocytes." ► https://pubmed.ncbi.nlm.nih.gov/12100... "Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration." ► https://pubmed.ncbi.nlm.nih.gov/24993... What Percentage of Niacinamide is Effective? Is 4% Niacinamide even enough to get any results. The reality is a higher concentration doesnt always mean better results. For some niacinamides over 5% spike histamine levels causing allergic reactions. Differin Dark Spot Correcting Serum Ingredients The one other ingredient that stands out to me in this, is the hippophae rhamnoides oil. Which is known as sea buckthorn berry. It has a “unique unsaturated fatty acids, such as palmitooleic acid and gamma-linolenic acid, giving sea-buckthorn oil skin regeneration and repair properties. How to Use Differin Dark Spot Correcting Serum? Go ahead and use your gentle cleanser to wash your face. Once your face is clean. You can use your toner if you have one. Next, use a pea sized amount directly on the dark spots that you are trying to fade. After, wait about 15 minutes, use your moisturizer, then your sunscreen. How to Use Adapalene and Niacinamide Together? If your trying to combine it with differin adapalene or your retinols or retinoids. You definitely want to wait until the purging period is over with any products that increase cell turnover. DISCLAIMER: This video is for information only and should not be used for the diagnosis or treatment of medical conditions. Dr. Arsalan Aspires has used all reasonable care in compiling the information but make no warranty as to its accuracy. Always consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions. “As an Amazon Associate I earn from qualifying purchases.”