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Actos | Medicine Information Actos is a brand name for the drug pioglitazone, which is used to treat type 2 diabetes. Pioglitazone is a member of the thiazolidinedione class of drugs and works by improving insulin sensitivity in the body, which helps to lower blood sugar levels. Actos is usually taken orally once daily, with or without food. The dosage may vary depending on the patient's medical history, response to treatment, and other factors. It is important to take Actos exactly as prescribed by a healthcare provider and to monitor blood sugar levels regularly while taking the medication. Like all medications, Actos may cause side effects, some of which may be serious. Common side effects of Actos include weight gain, edema (swelling), and headache. More serious side effects may include liver problems, heart failure, and an increased risk of bladder cancer, although the risk of bladder cancer is considered to be relatively low. It is important for patients to discuss any concerns they have about Actos with their healthcare provider and to report any unusual symptoms or side effects while taking the medication.