KS Insights: The Malaria Endgame (G1) скачать в хорошем качестве

KS Insights: The Malaria Endgame (G1)

About Keystone Symposia Insights Keystone Symposia Insights are panel discussions recorded on digital video that feature Keystone Symposia meeting organizers discussing the state of their respective fields. These thought leaders provide perspectives on current and future trends. The panel is asked to discuss the following topics: What is the state of this field? (What did we learn at the meeting?) Where is the field heading? What are the opportunities and challenges ahead? ___ Keystone Symposia Conference: The Malaria Endgame: Innovation in Therapeutics, Vector Control and Public Health Tools (G1) Organizer(s): Thierry Diagana, Philip Welkhoff and Flaminia Catteruccia October 30—November 2, 2019 Hilton Addis Ababa • Addis Ababa, Ethiopia #KSmalaria Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation Summary of Meeting: Malaria is most prevalent in the tropical belt and many malaria endemic countries have now engaged in elimination programs. However, we are facing a public health crisis because we have lost many of the public health tools that enabled the progress we have made to date. Many drugs are useless in most areas and resistance is threatening even artemisinin-based combination therapy (ACT). Diagnostics, bed-nets and insecticides are also losing their effectiveness and the Plasmodium vivax (P. vivax) parasite is finding new ways to transmit in Duffy negative patients. At the same time, there are multiple emerging threats such as artemisinin drug resistance, the rise of P. vivax malaria prevalence, and the discovery of the parasite Plasmodium knowlesi (P. knowlesi) in humans. However, there are some interesting developments such as deploying older suboptimal drugs in new, innovative and targeted control approaches like seasonal malaria chemoprevention (SMC) or intermittent preventive treatment of pregnant women/ infants (PTi/p). There are new drugs on the horizon that have pharmacological properties compatible with single dose cures and could prove to be powerful tools in the fight against malaria. For example, mass drug administration has demonstrated substantial impact as an intervention for Plasmodium elimination. By learning from recent successes in malaria elimination, epidemiological models of malaria transmission can be updated, and the impact of new interventions will critically inform the malaria endgame strategy. The conference is organized around three themes: defeating resistance (both to drugs and to insecticides), leveraging data science to better understand disease transmission and innovation in vector control strategies. This program will assess the current threats and gaps in our malaria armamentarium to enable malaria elimination and discuss the emerging innovative approaches for antimalarial drug discovery and development. For more details on this Keystone Symposia meeting, visit: https://www.keystonesymposia.org/19g1 ___ Copyright Keystone Symposia, 2019. All rights reserved. About Keystone Symposia: Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists. Visit Keystone Symposia at: https://www.keystonesymposia.org Visit Virtual Keystone Symposia at: https://virtual.keystonesymposia.org/ For more videos:    / keystonesymposia   Follow us on Twitter:   / keystonesymp   Like us on Facebook:   / keystonesymposia   Link to us on LinkedIn:   / keystone-symposia-on-molecular-and-cellula...