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October 27th, 2016 This MPG Primer was originally streamed live to YouTube. This version has been edited for time. Stephen Schaffner Computational Biologist Broad Institute Natural selection and human genetic variation. The Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease. Experts from across the Broad Institute community give in-depth introductions to the basic principles of complex trait genetics, including human genetic variation, genotyping, DNA sequencing methods, statistics, data analysis, and more. Videos of these sessions are made freely available for viewing here and are geared toward a wide audience that includes research technicians, graduate students, postdoctoral fellows, and established investigators just entering the field. For more information, please visit: -Program in Medical Population Genetics (http://www.broadinstitute.org/node/224/) -Primer videos (http://www.broadinstitute.org/node/1339/) Copyright Broad Institute, 2016. All rights reserved.