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Peripheral odontogenic keratocyst POKC treatment clinical manifestations literature review odontogenic keratocyst buccal mucosa recurrence surgery microscopic excision. Explore the rare peripheral odontogenic keratocyst (POKC), an extraosseous variant of odontogenic keratocyst (OKC). This video delves into clinical manifestations, including swelling, pain, and restricted mouth opening, often affecting the buccal mucosa and gingiva. Learn about diagnosis via imaging like CT and MRI, and treatment approaches such as enucleation, curettage, marsupialization, and complete excision under microscopic guidance. We review two patient cases from Beijing Stomatological Hospital, highlighting initial recurrences after conservative treatments and successful outcomes with adherent tissue removal using surgical microscopes. The literature review covers 51 reported cases, discussing origins from dental lamina remnants, associations with Gorlin-Goltz syndrome, and recurrence rates—emphasizing complete excision for better prognosis. Key highlights include male predominance, average age 54, and high recurrence in buccal mucosa. Discover why microscopic excision reduces damage to adjacent tissues and why long-term follow-up over 3 years is crucial. This comprehensive guide aids dentists, oral surgeons, and medical professionals in managing POKCs effectively.