Tocilizumab pre-treatment reduced cytokine release syndrome in RRMM pts receiving cevostamab. скачать в хорошем качестве

Tocilizumab pre-treatment reduced cytokine release syndrome in RRMM pts receiving cevostamab.

Dr. Suzanne Trudel, Princess Margaret Cancer Centre, discusses the results of a tocilizumab (TCZ) pretreatment arm of the ongoing Phase I study of cevostamab (an FcRH5xCD3 TDB) to see if a single dose of TCZ prior to cevostamab reduces the incidence of cytokine release syndrome. Background: Blockade of the IL-6 receptor cytokine with monoclonal antibodies like tocilizumab (TCZ) is crucial in managing both CAR-T and T-cell dependent bispecific monoclonal antibody (TDB) induced cytokine release syndrome (CRS). Studies show that inhibiting IL-6, IL-1, or TNF-α signaling before TDB administration can prevent CRS without affecting anti-tumor activity. To confirm this in clinical trials, a TCZ pretreatment arm was added to the ongoing Phase I study (NCT03275103) of cevostamab (an FcRH5xCD3 TDB) to see if a single dose of TCZ prior to cevostamab reduces the incidence of CRS. Conclusions: Clinical data from the GO39775 study shows for the first time that TCZ pretreatment can significantly reduce the risk of developing TDB-induced CRS without an apparent impact on anti-myeloma activity. The data support additional investigation of the use of anti-cytokine pretreatment with the goal of substantially reducing the frequency and potentially the severity of CRS. Authors: Suzanne Trudel, MD Nizar J. Bahlis, MD, Andrew Spencer, Rayan Kaedbey, MD, Paula Rodriguez Otero, MD, Simon J Harrison, MD, Chihunt Wong, Grant R. Goodman, MD, Rin Nakamura, Voleak Choeurng, James Cooper and Maria-Victoria Mateos, MD ASH Abstract #567: https://ash.confex.com/ash/2022/webpr... _______________ Improving Lives | Finding the Cure Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy. Subscribe to our channel:    / imfmyeloma   Visit our website at: https://www.myeloma.org Find us online: Facebook: @myeloma |   / myeloma   Twitter: @IMFMyeloma |   / imfmyeloma   Instagram: @imfmyeloma |   / imfmyeloma   LinkedIn:   / international-myeloma-foundation   Support the IMF | Donate Now! https://secure.myeloma.org/page/40697... Category Nonprofits & Activism License Standard YouTube License In most cases, captions are autogenerated by YouTube.