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Acetylcholine and ADHD

Main Chapters: 00:00 Intro - Acetylcholine and ADHD 00:11 Take home message 01:27 What is Aceytlcholine? 06:01 Drugs that Affect the Aceytlcholine System 13:18 New Medication - Cobenfy (Xanomeline-Trospium Chloride) Acetylcholine is an important neurotransmitter abundant in the body and brain, but it gets far less press than dopamine or serotonin, which are present in far smaller quantities. Most of the focus on acetylcholine is directed at plant and spider poisons that interfere with the acetycholine system. But Cobenfy, a new anti-schizophrenia medicine that binds to acetycholine receptors in the prefrontal cortex may be a game changer, not just for schizophrenia, but for additional mental health conditions. Preliminary evidence suggests that this agent can enhance both cognitive and executive functions that are based in the prefrontal cortex. It, or related agents, may prove helpful for ADHD, dementia, and other conditions. ----- Free link to my Medium Article on Acetylcholine and ADHD: https://medium.com/wise-well/lets-sto... Follow   / dockruse   on Medium for hundreds of full length articles on this subject and more! Access to Full Medium articles requires paid membership. ----- References: FDA approves first schizophrenia drug with new mechanism of action since 1950s (Cobenfy 2024) https://www.nature.com/articles/d4157... Cobenfy Falls Short of Statistical Significance as Additional Treatment for Schizophrenia in Phase III Clinical Trial (2025) https://www.appliedclinicaltrialsonli... Targeting the Nicotinic Cholinergic System to Treat Attention-Deficit/Hyperactivity Disorder: Rationale and Progress to Date (2014) https://pmc.ncbi.nlm.nih.gov/articles... Sofinicline: a novel nicotinic acetylcholine receptor agonist in the treatment of attention-deficit/hyperactivity disorder (2014) https://www.tandfonline.com/doi/10.15... Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease (1997) https://jamanetwork.com/journals/jama... Full Chapter list: 00:00 Intro - Acetylcholine and ADHD 00:11 Take home message 01:27 What is Aceytlcholine? 01:56 Aceytlcholine Receptor Systems 02:56 How the Body Uses Aceytlcholine 03:48 Aceytlcholine and the Brain 05:04 Conditions Related to Aceytlcholine 06:01 Drugs that Affect the Aceytlcholine System 06:11 Plant Poisons 08:01 Medications 09:54 Cholinesterase Inhibitors 10:37 Nicotine 12:54 Wellbutrin (Buproprion) 13:18 New Medication - Cobenfy (Xanomeline-Trospium Chloride) 16:24 Potential Side Effects of Cobenfy 17:08 Other Potential Uses of Cobenfy 18:17 Outro ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuroatypical brains can optimize their functioning in our shared, and somewhat strange, world. ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of Politics related videos have an orange background. Dr. Kruse has posted videos in the "Videos", "Live", and "Shorts", sections of this channel. You're welcome to email him with topics you want discussed or people you think he should interview. [email protected] #health #mentalhealth #adhd #acetylcholine