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#TechThursday

In a biological lab where genetic #engineering done, the analysis of DNA is a very important task. Nanopore sequencing is a way to analyse single #DNA or #RNA molecules and the MinION offers a platform to do this in a straightforward and very high throughput manner. But how does it work? As it says in the name already, a protein nanopore is embedded in a polymer membrane. This membrane is electrically resistant and therefore, the ionic current can pass through and create a voltage across the membrane. If now a molecule passes through the pore, the current changes slightly and this change can be measured easily. If a long strand of DNA passes through such a membrane, the different nucleotides G, A, T and C, will disrupt the current differently. This eventually results in a pattern which only needs to be decoded to get back to your DNA sequence. It’s as simple as that!🤓 Since it’s so simple and quick, nanopore sequencing finds wide applications in various fields ranging from human or plant genome sequencing to monitoring viral pathogens or even antibiotic resistance. Have a nice Thursday everyone! #NCCR #NCCRmse #nanopore #sequencing