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PNH is a rare but potentially serious blood disease affecting people of all ages. Although some of the features of this disease, such as hemolysis inside of the blood vessels or appearance of red urine, have been known for over 100 years, many aspects of PNH remain a mystery. As with other "orphan" diseases, the progress in their understanding is slow. For physicians and scientists who study this disease, it is often frustrating that they are only able to give limited answers and explanations to many of the questions that PNH patients have. Only recently have we learned the complicated mechanisms and pathologic relationships leading to the development of this disease. This webinar provides an advanced understanding of PNH, more specifically hemolytic anemia, pancytopenia, and thrombosis.