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In this video, Margaret Shipp, MD, Dana-Farber Cancer Institute, Boston, MA, notes that the ability to molecularly classify subtypes of diffuse large B-cell lymphoma (DLBCL) has significantly improved over the past decade, particularly with advancements in polyclonal sequencing and the ability to sequence formalin-fixed paraffin-embedded samples. Dr Shipp highlights an emerging consensus in the field regarding the basis of genetic heterogeneity in DLBCL and emphasizes the need to develop strategies to prospectively capture this information in patients to inform targeted therapies and clinical trial design. This interview took place at the 22nd International Workshop on Non-Hodgkin Lymphoma (iwNHL 2025), held in Cambridge, MA. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.