Jeremy Barr - Discovery and Characterisation of Temperate Gut Bacteriophages | S02 MVIF.16 скачать в хорошем качестве

Jeremy Barr - Discovery and Characterisation of Temperate Gut Bacteriophages | S02 MVIF.16

Title of the presentation: Discovery and Characterisation of Temperate Gut Bacteriophages Speaker: Jeremy Barr Speaker's Twitter profile:   / jeremyjbarr   More info on this event: https://www.microbiome-vif.org/en-US/... Join us at the next meeting (free registration!): https://www.microbiome-vif.org/ And you can join us on Twitter:   / microbiomevif   Abstract of this talk: Bacteriophages are ubiquitous across all environments and influence their bacterial hosts in diverse ways. Within the human gut the bacterial concentration is estimated to be around 1011 cells per gram of faeces, yet the phage concentration is significantly lower at around 109 phages per gram of faeces. However, these raw counts fail to capture the prophages, which are integrated phages residing withing a bacterial host chromosome. Prophages can constitute up to 20% of the host bacterial genome, greatly impacting their host’s function, evolution, and diversification. Here we characterised a large collection of bacterial isolates originating from the human gut and identify their prophage elements. Using a broad panel of induction conditions under anaerobic conditions we identify and begin to experimentally characterise these novel and actively replicating temperate phages of the human gut.