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Episode Description In this episode of Cutting to the Case, Dr. Amanda D. Henderson, Chief of the Division of Neuro-Ophthalmology at the Wilmer Eye Institute of Johns Hopkins University School of Medicine, explores how data-driven innovation is transforming the practice of neuro-ophthalmology. As the Frank B. Walsh Professor and a leading educator in the field, Dr. Henderson discusses strategies to improve documentation efficiency, streamline medical record workflows, and enhance patient care through precision data capture. The conversation delves into her development of a machine learning–based clinical decision support system designed to triage patients presenting with papilledema, highlighting how artificial intelligence can strengthen diagnostic accuracy and reduce time to intervention. Dr. Henderson also reflects on her dual role as a clinician and mentor, examining how the integration of informatics, education, and patient-centered care is redefining the future of ophthalmology. Guest Biography Dr. Amanda D. Henderson is the Chief of the Division of Neuro-Ophthalmology at the Wilmer Eye Institute of Johns Hopkins University School of Medicine, where she holds the Frank B. Walsh Professorship in Neuro-Ophthalmology. She completed her ophthalmology residency at the Medical College of Georgia and a fellowship in neuro-ophthalmology at the Bascom Palmer Eye Institute in Miami. Her clinical expertise encompasses optic neuropathies, visual field disorders, and the interface between ocular and neurological disease. A pioneer in integrating data science into clinical care, Dr. Henderson leads research applying machine learning and quality improvement methodologies to enhance diagnostic precision and care delivery in neuro-ophthalmology. She also serves as Associate Ophthalmology Residency Program Director and Neuro-Ophthalmology Fellowship Director at Johns Hopkins, guiding the next generation of physician-scientists with a focus on innovation, rigor, and empathy.