Easy-to-Grasp Explanations: Bleomycin, the Cell Cycle Specific Anticancer Antibiotics скачать в хорошем качестве

Easy-to-Grasp Explanations: Bleomycin, the Cell Cycle Specific Anticancer Antibiotics

In this video, we'll delve into Bleomycin, a potent anticancer antibiotic known for its unique mechanism and side effects. It targets cancer cells in the G2/M phase by inducing DNA damage and forming free radicals. Despite its effectiveness against Testicular cancer and Hodgkin lymphoma, Bleomycin is infamous for causing Pulmonary Fibrosis and skin pigmentation changes. Understanding its mechanism and cell cycle specificity is key for exams like USMLE Step 1. Stay tuned for more on Bleomycin's role in cancer treatment. #bleomycin #cellcycle #Anticancer 【Notes】 ▹This video was created based on data as of March 2024, with the purpose of supporting medical students in their exam preparations. ▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited. 【Contents】 00:00 key points for your exam 00:21 Bleomycin, Mechanism of Action 01:45 Side Effect 02:13 A final confirmation: Cell cycle and Bleomycin, side effecte 【Reference and figure】I express my gratitude and respect for your wonderful achievements. 1. Carmen Avendaño, J. Carlos Menéndez, Chapter 4 - Anticancer strategies involving radical species, Editor(s): Carmen Avendaño, J. Carlos Menéndez, Medicinal Chemistry of Anticancer Drugs (Third Edition), Elsevier, 2023, Pages 165-235, ISBN 9780128185490, https://doi.org/10.1016/B978-0-12-818.... (https://www.sciencedirect.com/science...) 2. Mayo clinic, disease & Condition, Testicular cancer. https://www.mayoclinic.org/diseases-c... 3. PDQ Adult Treatment Editorial Board. Hodgkin Lymphoma Treatment (PDQ®): Patient Version. 2023 Nov 17. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. Available from: https://www.ncbi.nlm.nih.gov/books/NB... 4. The Free dictionary by FARLEX, “Reed-Sternberg cell” https://medical-dictionary.thefreedic... 5. Murray V, Chen JK, Chung LH. The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA. Int J Mol Sci. 2018 May 4;19(5):1372. doi: 10.3390/ijms19051372. PMID: 29734689; PMCID: PMC5983701. 6. Richard Harth, Arizona State University, “ cutting cancer to pieces: New research on bleomycin”. PHYS ORG. April 30, 2014 https://phys.org/news/2014-04-cancer-... 7. Roy B, Hecht SM. Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage. J Am Chem Soc. 2014 Mar 19;136(11):4382-93. doi: 10.1021/ja500414a. Epub 2014 Mar 8. PMID: 24548300; PMCID: PMC3988684. 8. Tetikkurt, Cuneyt, Deniz Ongel and Seza Tetikkurt. “A case of bleomycin-induced lung toxicity.” Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 88 3 (2018): 981 . DOI:10.4081/monaldi.2018.981 9. Khmamouche MR, Debbagh A, Mahfoud T, Aassab R, Lkhoyaali S, Ichou M, Errihani H. Flagellate erythema secondary to bleomycin: a new case report and review of the literature. J Drugs Dermatol. 2014 Aug;13(8):983-4. PMID: 25116979.