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In October 2024, a European nuclear reactor, supplier of materials used in the production of Tc99, went down for a second time in just 18 months. The temporary shutdown left surgeons across the world scrambling for a non-inferior alternative to get through their patient lists without delay. But which solutions can truly offer that? This webinar addresses how surgeons need to consider a future without Tc99 as an option for sentinel lymph node biopsy, and the effectiveness and reliability of the potential replacements. It assesses the long-term availability of radioactive isotopes, reviews the proven clinical efficacy of tracers, before analysing the logistical benefits, opportunities for further utilisation, advanced techniques, and additional benefits for patients. Moderator Ash Kothari, Guy's Hospital, London, UK Speakers Andreas Karakatsanis, Uppsala University, SE Marc Thill, Agaplesion Markus Hospital, Frankfurt, DE Kandace McGuire, VCU Massey, US Programme 0:00-9:54 Introduction - A. Kothari 9:55-26:20 Tc99: How much is left - and how long do we have? - K. McGuire 26:30-50:34 Alternative sentinel lymph node biopsy tracers and logistical benefits of switching to the alternatives (inc. business case) - M.Thill 50:51-1:14:08 How to improve patient outcomes by switching your SLNB tracer - A. Karakatsanis 1:14:10-1:33:05 Q&A Session