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How Cocaine Rewires the Brain: Long-Term Effects Explained | Dr. Ferghal Armstrong | MedHeads If you've ever wondered what cocaine really does to your brain—not just the highs, but the long-term consequences—this episode is a must-watch. Discover how this powerful drug hijacks your brain’s core systems, from the prefrontal cortex (decision-making) to the amygdala (emotions) and hippocampus (memory). You'll see how repeated use leads to devastating effects on memory, emotional regulation, and impulse control—and even increases the risk of drug-induced psychosis. With insights from Dr. Ferghal Armstrong, we unpack neuroimaging evidence that shows: -Gray matter shrinkage -Dopamine receptor loss -And how these changes show up in real life: blunted pleasure, rising anxiety, and stress sensitivity that traps users in a vicious cycle. This is not just about addiction—it's about how a single substance can reshape who you are. Prepare to be shocked, informed, and more aware than ever. Subscribe to MedHeads for more deep dives into brain science, substance use, and the real stories behind mental health. Chapters 00:00:00 Introduction and Recap on Previous Episode 00:00:35 Neuroanatomical Damage from Chronic Cocaine Use 00:01:30 Cardiovascular Effects and Stroke Risks 00:02:38 Neurochemical Imbalances and Neurotransmitter Dysregulation 00:03:42 Psychological Impairments from Chronic Cocaine Use 00:04:38 Emotional Dysregulation and Increased Impulsivity 00:05:44 Structural Brain Changes in Chronic Cocaine Users 00:06:38 Long Term Recovery Challenges 00:07:40 Conclusion and Final Thoughts #cocaine #brainhealth #medheads #addictionscience #mentalhealthawareness