The Science of Aging and How to Slow It Down | Dr. Matt Kaeberlein | The Proof Podcast EP 249 скачать в хорошем качестве

The Science of Aging and How to Slow It Down | Dr. Matt Kaeberlein | The Proof Podcast EP 249

In Episode #249, I’m joined by biologist Dr Matt Kaeberlein for a deep dive into biological aging. 👇Visit The Proof website for supporting studies and the full show notes 👇 https://theproof.com/podcast/ Humans have long been interested in the phenomenon of aging – today, scientists across the world are pursuing ways we can increase our lifespan. From pharmaceutical interventions to nutrition, supplements to sleep, there are endless roads to pursue. In Episode #249, I sit down with Professor Matt Kaeberlein to explore what we know about biological aging, and whether we can really achieve a significantly longer life. Dr Matt Kaeberlein is the Chief Science Officer at Optispan Geroscience and a Professor of Laboratory Medicine and Pathology at the University (UW) School of Medicine. His research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote health span and improve quality of life for people and companion animals. Dr Kaeberlein has published more than 250 scientific papers and has been recognized by several prestigious awards including young investigator awards from the Ellison Medical Foundation and the Alzheimer’s Association, the Star in Aging Research Award, the Murdock Trust Award, the NIA Nathan W. Shock Award, and the Robert W. Kleemeier Award for outstanding research in the field of gerontology. In this episode, we examine where the science surrounding biological aging is now. You’ll gain a comprehensive overview of biological aging, including health span vs life span, and how we can extend them. Dr Kaeberlein explains the significance of genetics vs environmental factors, and offers his informed perspective on cell reprogramming, protein restrictions, polyphenols (including resveratrol), and much more. Specifically, we discuss: 00:00 - Intro 03:42 - Aging and disease 17:41 - Evolutionary conserved processes and human life span 28:09 - Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? 34:06 - Aging process and the burden of senescence cells 45:08 - Keys to a longer, healthier life 53:43 - Nature and aging 55:58 - Sleep and exercise 1:15:23 - Calorie restriction, longevity, and prolonged fasting 1:32:14 - Protein restriction and its implications 1:43:50 - Plant protein vs animal protein 1:53:26 - Natural occurring polyphenols and supplements related to longevity 2:14:14 - Rapamycin and rapamycin derivatives 2:30:09 - Anti-aging compounds 2:51:28 - Ethical implications of prolonging the life 2:57:43 - Outro With so much conflicting information available online ­– including from science communicators – it was very informative to hear a leading expert’s perspective in this conversation. Dr Kaeberlein approaches this topic with nuance and evidence, providing measured insight in a field often clouded by extrapolation and misinformation. There’s a lot to learn from this detailed conversation, and I hope you gained some valuable takeaways. Connect with Dr Matt Kaeberlein: Twitter:   / mkaeberlein   LinkedIn:   / mkaeberlein   Website: https://kaeberlein.org/ The Dog Aging Project: https://dogagingproject.org/ If you have any additional questions you would like answered in the future, let me know in the comments. The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. Enjoy, friends. Simon ==== Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/. • The Proof with Simon Hill - https://theproof.com/podcast/ • Book: The Proof is in the Plants - https://theproof.com/book/ • Apple Podcast - https://podcasts.apple.com/gb/podcast... • Spotify - https://open.spotify.com/show/7bAIJCV... • Instagram -   / theproof   • Twitter -   / theproof   • Facebook -   / theproofwithsimonhill   • Plant-Based Ferments Guide - https://theproof.com/ferments/ • Two week meal plan - https://theproof.com/mealplan/ • Plant Performance - https://theproof.com/plant-performance/ • Use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends.