甲状腺球蛋白增高就一定是甲状腺癌吗 段东升 山西省肿瘤医院 скачать в хорошем качестве

甲状腺球蛋白增高就一定是甲状腺癌吗 段东升 山西省肿瘤医院

甲状腺球蛋白增高就一定是甲状腺癌吗 段东升 山西省肿瘤医院 Tg是甲状腺产生的一种特异性蛋白，临床上血清Tg测定对甲状腺疾病的诊断缺乏特异性价值。甲状腺良性疾病和甲状腺恶性疾病均可能引起血清Tg的升高，前者包括结节性甲状腺肿、乔本氏甲状腺炎、甲状腺功能亢进以及药物或者特殊食物的影响。后者主要指分化型甲状腺癌（DTC），因此临床上一般不将血清Tg测定用于甲状腺癌的术前诊断。但当正常甲状腺组织被全部切除后（清甲），DTC细胞就成了血清Tg的唯一生成来源，此时若在血清中检测有Tg往往提示甲状腺癌病灶残留或复发。Tg是DTC患者清甲治疗后疗效判断和动态监测的主要判断指标，是对DTC进行病程监测后续效果评估和预后诊断的重要判断依据，所以说甲状腺球蛋白增高并不意味着一定是甲状腺癌。 Is the increase of thyroglobulin necessarily thyroid cancer TG is a specific protein produced by thyroid, There is no specific value of serum TG in the diagnosis of thyroid diseases. Thyroid benign diseases and thyroid malignant diseases may cause the increase of serum TG, The former includes nodular goiter, Chopin's thyroiditis, hyperthyroidism and the influence of drugs or special food. The latter mainly refers to differentiated thyroid cancer (DTC), Therefore, serum Tg is generally not used in preoperative diagnosis of thyroid cancer. But when the normal thyroid tissue is completely removed (cleaned), DTC cells become the only source of serum TG, At this time, if TG is detected in serum, it often indicates the residual or recurrence of thyroid cancer. TG is the main index to judge the curative effect and dynamic monitoring of patients with DTC, It is an important judgment basis for the follow-up effect evaluation and prognosis diagnosis of DTC, So high thyroglobulin does not mean thyroid cancer.