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This video recounts the origins of the superoxide sentinel hypothesis (SSH) of mitochondrial quality control (MQC). You will be introduced to some of the people and events that led to the proposal of the hypothesis. You will learn about the hypothesis as I tell this story. You will get an overview of the steps involved in SSH of MQC. Other videos in this series are in this playlist: • Superoxide sentinel hypothesis of mitochon... If you want to hear my personal story, I suggest this video. • William Curtis reduced Parkinson's sympto... I made this video with Camtasia Audiate using "Andy" as the narrator. For extra reading check out the chapter on radiation mitigation https://drive.google.com/file/d/0B0Pm... One can find Pacher et al review of NO and peroxynitrite here: https://ncbi.nlm.nih.gov/pmc/articles... 00:00 Introduction and highlights from chapter 1 01:19 The first suggestion of the theory 02:52 What I knew from Veech's radiation study 06:19 Patrick Bradshaw 07:07 Acknowledgments