Colchicine, Cancer and the Flame Lily (Gloriosa superba) скачать в хорошем качестве

Colchicine, Cancer and the Flame Lily (Gloriosa superba)

In this, the third episode of our ongoing series on the extraordinary Flame Lily (Gloriosa superba), Gus talks us through some of the medicinal applications of the plant's roots and tubers. Specifically he focuses on the compound colchicine, found in the tuber. Colchicine is already FDA-approved in the treatment of gout, but is currently being explored for its anti-cancer activity. Join us as we delve deeper into the medicinal uses of the Flame Lily. For more videos from the African Plant Hunter, please subscribe to this channel or check the following links:    / @africanplanthunter   https://africanplanthunter.com/   / africanplanthunter     / afriplanthunter     / africanplanthunter   For more on the use of colchicine in the treatment of cancer, see: Lu Y, Chen J, Xiao M, et al. An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm Res 2012; 29:2943–2971 Lin ZY, Wu CC, Chuang YH, et al. Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma. Life Sci 2013; 93:323–328. Bhattacharyya B, Panda D, Gupta S, et al. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Med Res Rev 2008; 28:155–183. Bhattacharya S, Das A, Datta S, Ganguli A and Chakrabarti G: Colchicine induces autophagy and senescence in lung cancer cells at clinically admissible concentration: potential use of colchicine in combination with autophagy inhibitor in cancer therapy. Tumour Biol 2016. Huang Z, Xu Y and Peng W: Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. Mol Med Rep 12: 5939-5944, 2015. G. Sivakumar. Colchicine semisynthetics: chemotherapeutics for cancer?. Curr Med Chem. 2013; 20: 892–898. Colchicine Significantly Reduces Incident Cancer in Gout Male Patients: A 12-Year Cohort Study Ming-Chun Kuo, Shun-Jen Chang, Ming-Chia Hsieh Medicine (Baltimore) 2015 Dec; 94(50): e1570. Published online 2015 Dec 18. Colchicine: an ancient drug with novel applications B. Dasgeb, D. Kornreich, K. McGuinn, L. Okon, I. Brownell, D. L. Sackett Br J Dermatol. Published in final edited form as: Br J Dermatol. 2018 Feb; 178(2): 350–356. Published online 2018 Jan Lead Phytochemicals for Anticancer Drug Development Sukhdev Singh, Bhupender Sharma, Shamsher S. Kanwar, Ashok Kumar Front Plant Sci. 2016; 7: 1667. Published online 2016 Anticancer Activity of Natural Compounds from Plant and Marine Environment Anna Lichota, Krzysztof Gwozdzinski Int J Mol Sci. 2018 Nov; 19(11): 3533. Published online 2018 #Flamelily #Africanplanthunter #Cancer #Africa