4. Anti- Neoplastic Drugs: Alkylating Agents & Platinum Compunds: Alkylating Agents скачать в хорошем качестве

4. Anti- Neoplastic Drugs: Alkylating Agents & Platinum Compunds: Alkylating Agents

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning   1. Anti- Neoplastic Drugs: Alkylating Agents & Platinum Compunds: Alkylating Agents ------------------------------------------------------------------------------------------------------------------------------------------- Platinum compounds (e.g., cisplatin, carboplatin, oxaliplatin) are alkylating-like agents used widely in chemotherapy to treat various solid tumors including testicular, ovarian, bladder, and colorectal cancers 🏥⚡. These drugs form platinum-DNA adducts by binding to guanine bases, causing cross-linking and inhibition of DNA replication 🔬🧬. Cisplatin is the prototype of this group, known for its broad-spectrum anti-tumor activity but also notable toxicities such as nephrotoxicity (acute kidney injury), ototoxicity (hearing loss), neurotoxicity, and severe nausea/vomiting ⚠️🎧. Amifostine can be administered as a renal-protective agent, and adequate hydration is essential to reduce kidney damage 🚰💊. Carboplatin, a cisplatin analog, has less nephrotoxicity and ototoxicity but can cause myelosuppression, particularly thrombocytopenia 💉🔴. Oxaliplatin is particularly effective in colorectal cancer regimens (e.g., FOLFOX), though it often triggers neuropathy, exacerbated by cold temperatures ❄️⚠️. As with other DNA-alkylating drugs, resistance can develop via increased DNA repair mechanisms, reduced drug uptake, and active efflux pumps, necessitating combination regimens and close toxicological monitoring 🏆🔄. By targeting rapidly dividing cancer cells, platinum compounds have significantly improved survival outcomes in many malignancies, marking them as a key pillar of modern oncology 💪🌟. #PlatinumCompounds #Cisplatin #Carboplatin #Oxaliplatin #AlkylatingAgents #Chemotherapy #Oncology #Nephrotoxicity #Ototoxicity #Nausea #DNAAdducts #MedicalScience #USMLE #NEETPG #GlobalHealth #SaveLives #Pharmacology #CancerTreatment #RationalDrugUse