Detailed Overview of 25I-NBOH (CAS: 919797-20-9): Mechanism of Action, Properties, and Applications скачать в хорошем качестве

Detailed Overview of 25I-NBOH (CAS: 919797-20-9): Mechanism of Action, Properties, and Applications

our new link    / @jyonaguilar   25I-NBOH, CAS: 919797-20-9 also known as 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-hydroxyphenyl)methyl]ethanamine, is a potent synthetic compound categorized under the phenethylamine and N-benzyl-oxy derivatives. It is structurally related to the 2C family of psychedelic phenethylamines and functions primarily as a selective agonist for the serotonin receptor subtype 5-HT2A. 25I-NBOH exerts its effects by binding to and activating the 5-HT2A receptors, which are predominantly found in the central nervous system. The activation of these receptors is associated with the modulation of neurotransmitter systems, leading to altered perception, mood, and cognition. The compound mimics the action of serotonin, a key neurotransmitter, thereby inducing its psychedelic effects. Upon binding to the 5-HT2A receptors, 25I-NBOH causes a conformational change in the receptor structure, triggering a cascade of intracellular events. This includes the activation of phospholipase C (PLC), which subsequently catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). These molecules serve as secondary messengers, leading to the release of calcium ions from intracellular stores and activation of protein kinase C (PKC), respectively. The culmination of these signaling events contributes to the characteristic psychoactive effects observed with 25I-NBOH. Applications and Uses While primarily researched for its psychoactive properties, 25I-NBOH has been utilized in scientific studies to explore the functions of 5-HT2A receptors and their role in neuropsychological processes. Due to its potent receptor binding affinity, it serves as a valuable tool in neuropharmacological research. Safety and Regulations The safety profile of 25I-NBOH remains largely under-researched, with limited data on its long-term effects and potential toxicity. As a result, its use is often restricted, and it is classified as a controlled substance in many jurisdictions. Conclusion 25I-NBOH (CAS: 919797-20-9) is a significant compound within the realm of psychoactive substances, notable for its potent activity at 5-HT2A receptors. While it offers valuable insights for scientific research, caution is advised due to its potent effects and regulatory status.