Sequencing a DNA analog composed of artificial bases скачать в хорошем качестве

Sequencing a DNA analog composed of artificial bases

What if DNA didn’t use A, C, G, or T? Andrew Laszlo and Christopher Thomas describe how they were able to successfully sequence a synthetic DNA molecule made from four artificial bases (P, Z, S, and B) using a custom nanopore setup. This “ALIEN DNA”, , designed by FfAME - Foundation for Applied Molecular Evolution, mimics the structure of natural DNA but is completely orthogonal to biological systems, making it ideal for applications in synthetic biology, molecular diagnostics, and even astrobiology. Using variable-voltage nanopore sequencing, the team achieved single-molecule, label-free reads of these artificial strands with impressive accuracy. This breakthrough shows that nanopore technology can be adapted to decode entirely new genetic alphabets, opening the door to designing and reading custom genetic systems. Don't forget to like, subscribe, and comment for more content! Read the full paper in Nature Communications: https://doi.org/10.1038/s41467-025-61... The analysis code are available: https://doi.org/10.6084/m9.figshare.2... Learn more about the NHGRI Genome Technology Opportunity Fund: https://genometdcc.org/opportunity-fu... UW Nanopore Biophysics Lab: https://depts.washington.edu/nanopore... Foundation for Applied Molecular Evolution: https://www.ffame.org/home.php #SyntheticDNA #NanoporeSequencing #Biotech