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Pulmonary Embolism management has officially changed. The 2026 AHA/ACC Guideline for the Evaluation and Management of Acute Pulmonary Embolism introduces a precision-based framework that replaces outdated “massive/submassive” terminology with a structured A–E classification system. In this masterclass, I break down the most important updates from the 2026 guideline (2026_Precision_PE_Guidelines) in a clear, high-yield format designed for: Medical Students Emergency Medicine Residents Internal Medicine Trainees ICU Physicians Board Exam Candidates I am Dr. Amr Elmoheen, Consultant in Emergency Medicine at Hamad Medical Corporation and Clinical Associate Professor at Qatar University, and in this session we translate guideline complexity into real Emergency Department decision-making. 🔴 What You Will Learn in This Video 🧠 1️⃣ The Paradigm Shift: From “Blunt Force” to Precision Medicine Why “massive” and “submassive” PE were insufficient The evolution from 2011 → 2019 → 2026 framework Why risk stratification now drives treatment (See the transition illustrated in the guideline visual summary 2026_Precision_PE_Guidelines) 🟢 2️⃣ The NEW A–E Clinical Classification System Category A – Subclinical Incidental, asymptomatic PE Category B – Symptomatic Low Risk Low clinical severity score Category C – Elevated Risk C1: Normal RV + normal biomarkers C2: Abnormal RV OR elevated biomarkers C3: Abnormal RV AND elevated biomarkers Category D – Incipient Failure (Normotensive Shock) Tissue hypoperfusion despite preserved BP Category E – Cardiopulmonary Failure Hypotension, shock, or cardiac arrest This system is granular, actionable, and prognostic. 🏥 3️⃣ Who Goes Home? Who Gets ICU? Categories A & B → Eligible for outpatient or early discharge Category C → Mandatory hospitalization Categories D & E → Immediate stabilization + PERT activation 💉 4️⃣ Anticoagulation Hierarchy Update LMWH preferred in initial phase DOACs preferred for maintenance Warfarin reserved in selected cases Special population updates: Pregnancy → LMWH (DOACs contraindicated) Cancer-associated thrombosis → DOACs preferred (with exceptions) 🚨 5️⃣ Advanced Therapies Strategy Systemic thrombolysis Catheter-directed lysis (CDL) Mechanical thrombectomy Surgical embolectomy When to consider intervention in: Category E1 Category D1/D2 🤝 6️⃣ PERT – A Multidisciplinary Mandate Class I recommendation for Categories C, D, and E. Emergency Medicine, Cardiology, Pulmonology, Hematology, Critical Care — unified under one response system. 📅 7️⃣ The 3-Month Checkpoint Mandatory functional reassessment Screen for CTEPH V/Q scan or echocardiography when indicated Post-PE care is now structured, not optional. This is not just a guideline update. It is a shift toward precision risk stratification and outcome-driven care. If this video helps you: 👍 Like 💬 Comment your toughest PE scenario 🔔 Subscribe for high-yield Emergency Medicine updates 📤 Share with your colleagues and residency groups Let’s build the most practical Emergency Medicine education platform globally. 🔎 Keywords 2026 AHA Pulmonary Embolism Guideline, Acute PE Management 2026, AHA ACC PE Update, Pulmonary Embolism Risk Stratification, A–E PE Classification, Massive vs Submassive PE Replacement, PE Shock Management, Normotensive Shock PE, PERT Team Activation, Anticoagulation PE 2026, DOAC vs LMWH PE, PE Board Exam Review, Emergency Medicine PE Update, Medical Student Exam Prep, ICU Pulmonary Embolism Management. 🔥 Hashtags #PulmonaryEmbolism #PE2026 #AHA2026 #EmergencyMedicine #CriticalCare #RiskStratification #PERT #DOAC #BoardExamPrep #MedicalStudents #DrAmrElmoheen