Signals, pH, and Discovery: Cracking GPCR Mysteries with Dr. Ian Chronis / скачать в хорошем качестве

Signals, pH, and Discovery: Cracking GPCR Mysteries with Dr. Ian Chronis /

What do ancient Greek history, beta-2 adrenergic receptors, and cancer signaling have in common? In this episode, we connect the dots with Dr. Ian Chronis—a freshly minted Ph.D. and incoming postdoc at the University of Michigan. Host Yamina Berchiche sits down with Ian for a deep and dynamic conversation about his scientific journey, his work on GPCR signaling beyond the plasma membrane, and the unexpected behavior of the proton-sensing receptor GPR65. From constitutive internalization to endosomal activation in acidic environments, Ian’s research brings powerful new insights into how GPCRs behave—and why it matters for cancer biology and immunotherapy. 📚 You’ll learn about: • Why Ian almost majored in Ancient Greek before falling for chemistry • How GPR65 challenges classical GPCR signaling models • The role of pH in receptor activation and internal signaling • Why understudied receptors are opening new therapeutic frontiers • How a great lab environment shapes great science 🧪 Curious about GPCR tools, signaling complexity, or what it means to think like a translational scientist? This episode is for you. 🎧 Listen, learn, and explore the GPCR universe—one episode at a time. 🔗 Subscribe and tap the bell so you never miss an update. ⏱️ Timestamps 01:08 – Meet Dr. Ian Chronis & his journey to a PhD 06:30 – How GPCRs “found” him through a lab rotation 10:30 – Beta-2 adrenergic receptor: proteomics & surprises 15:00 – GPR65: proton sensing, constitutive internalization, and cancer 20:00 – Signaling from acidic endosomes: a new paradigm 25:00 – From immunosuppression to tumor growth: why GPR65 matters 31:00 – Choosing a postdoc with purpose, tools & team culture 36:00 – Ian’s advice: embrace cross-disciplinary science & stay curious Hashtags: #GPCRpodcast #DrGPCR #GPR65 #GPCRresearch #cancerimmunotherapy #Gproteincoupledreceptors #GPCRscientistnetwork #pharmacology #translationalresearch #protonsensing #biomedicalscience Watch the complete episode at: https://www.ecosystem.drgpcr.com/dr-g... --- Dr. GPCR is dedicated to fostering a collaborative ecosystem focused on GPCRs. By connecting researchers, sharing knowledge, and facilitating partnerships, the #DrGPCR Ecosystem provides resources to support advancements in GPCR drug discovery. The ecosystem includes a variety of initiatives designed to inform and engage the scientific community, from courses and news updates to networking opportunities. 🧭 Links & Resources • Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/ • Dr. GPCR University Courses: https://www.ecosystem.drgpcr.com/gpcr... • Membership & Pricing: https://www.ecosystem.drgpcr.com/univ... • GPCR Weekly News: https://www.ecosystem.drgpcr.com/gpcr...