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What Do Hops Have to Do with Toothpaste

What if one of the most promising antimicrobial ingredients for toothpaste came from the same plant used to preserve beer? In this episode of Dental Formulator’s Playbook, Dr. Rob Karlinsey and co-host Tami explore an unexpected crossover between brewing science and oral care innovation. What do hops, Miller Brewing, and Procter and Gamble have to do with toothpaste? Quite a lot, it turns out. This conversation breaks down how hop compounds suppress lactobacilli in beer, why that same concept appeared in toothpaste patents decades ago, and how modern patent strategy may shape the next generation of oral care products. Highlights and Takeaways Why hops are not just about bitterness, but also act as preservatives by suppressing lactobacilli and preventing beer spoilage The surprising history of Miller Brewing filing an oral care patent in 1994, including toothpaste and mouthwash formulations that never reached market How hop cones are harvested and kiln dried to reduce moisture and spoilage risk What hops are made of, including cellulose, proteins, fats, resins, polyphenols, essential oils, and soluble fibers Why the resins, not the essential oils or fibers, are the most relevant fraction for oral care How hop resins are separated into soluble and insoluble fractions, and why the soluble fraction drives antimicrobial acid activity The difference between hop alpha acids and hop beta acids, and why alpha acids matter most for bitterness and bacterial control Why extremely low concentrations can still be biologically active, with hop alpha acids discussed at levels as low as 0.01 percent How patent claims work in practice and why claim language matters more than the length of the patent Why Procter and Gamble’s patent strategy expands beyond hop acids into additional resin derived compounds The growing research interest in prenylated flavonoids and how their fat-affinity influences absorption and biological behavior Why antimicrobial testing often fails to translate clinically once ingredients are placed into real toothpaste formulations 📲 Connect with Dr. Rob (Robert L. Karlinsey, PhD) 🌐 Website: customdentalformulations.com Robert L. Karlinsey, PhD Google Scholar Profile