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At the 24th Congress of the European Sleep Research Society, NeurologyLive spoke with Isabelle Lambert, MD, Sleep Unit, Clinical Neurophysiology, Timone Hospital, to discuss the results of a study that examined the effect of epileptic activities on physiological sleep activities in the hippocampus, and the consequences on long-term memory with intracranial EEG recordings. The results revealed a negative correlation between spike frequency and spindle frequency in the hippocampus, as reported in previous works. There was, however, a significant correlation between spike frequency during the first cycle of non-rapid eye movement (NREM) and a percentage of forgetting at the 1-week delay recall and recognition. This suggests that the interictal spikes interrupt the hippocampal neocortical transfer that should occur during NREM sleep. Read more: http://neurologylive.com/conferences/...