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Setting up a hydrogenation reaction presents several challenges, primarily related to safety. Handling hydrogen gas requires strict precautions due to its flammability and potential for explosion, especially under high pressure. Choosing the right catalyst (e.g., palladium, platinum, or nickel) and reaction conditions is crucial to ensure chemoselectivity and avoid over-reduction or unwanted side reactions. The reaction setup often involves specialized apparatus like pressure vessels (e.g., Parr reactors) or balloon systems (the black balloon in the video), which must be leak-free and properly maintained. Additionally, achieving complete hydrogen uptake and monitoring reaction progress can be difficult, requiring experience and careful optimization. This instructional video demonstrates how to safely perform a hydrogenation using an H₂ balloon to reduce a nitro group to an amine. #Hydrogenation #OrganicSynthesis #LabSafety #Catalysis #ChemistryLab #palladium To learn more about Selvita and our scientific initiatives, visit our website and social media. Website: https://selvita.com/our-science/ Linkedin: / selvita Facebook: / selvitagroup